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(VI) (DM) GcMAF for the treatment of cancer, autism, inflammation, viral and bacterial disease / Nagalase: Friend and Foe? / GcMAF: The Latest Discovery in Natural Cancer Treatments


These are some great articles on GcMAF and Nagalase. These articles show why Vitamin D and probiotics and essential fatty acids are so important for our immune system. Most Americans are deficient in Vitamin D. You want at least 10,000 IU per day. Flax Seed and Black seed oil is a good source of essential fatty acids. –MrT.


GcMAF for the treatment of cancer, autism, inflammation, viral and bacterial disease

By David Noakes

David Noakes
David Noakes

Human GcMAF, otherwise known as Vitamin D binding protein macrophage activating factor, holds great promise in the treatment of various illnesses including cancer, autism, chronic fatigue and possibly Parkinson’s. Since 1990, 59 research papers have been published on GcMAF, 20 of these pertaining to the treatment of cancer. 46 of these papers can be accessed through the

GcMAF is a vital part of our immune system which does not work without it; and is part of our blood. GcMAF stimulates the macrophage element of the immune system to destroy cancer cells. It also blocks the supply of nutrients to cancer cells by stopping blood vessel development to the site (anti-angiogenesis). Cancer cells are weakened and starved, making them more vulnerable to attack by the GcMAF stimulated macrophage system. Research has shown macrophage activation and stopping diseased blood vessel development can also help in various neurological diseases such as Parkinson’s, Alzheimer’s, rheumatoid arthritis, inflammatory conditions, and diabetic retinopathy.

In the case of autism, Dr. James Bradstreet has so far treated 1,100 patients with GcMAF with an 85% response rate. His results show a bell curve response with 15% of the patients showing total eradication of symptoms and 15% showing no response.

In addition, experimental and clinical evidence confirms that GcMAF shows multiple powerful anti-cancer effects that have significant therapeutical impact on most tumors, including breast, prostate, and kidney. GcMAF is created in the body by the release of two sugar molecules from a GcProtein molecule.

However, tumors release an enzyme known as Nagalase. Nagalase degrades GcProtein to the point it is unable to become GcMAF. Since GcMAF only lives for about a week in the body, without continuous conversion of GcProtein the stores of GcMAF are depleted rapidly in the presence of Nagalase. However, Nagalase can only destroy GcProtein and not GcMAF. Thus the introduction of external GcMAF through injection into the body has been shown to be effective.

GcMAF has no side effects of its own, but in [fewer than] 10% of cases the immune system, which will be rebuilt in just three weeks, can produce considerable side effects in autistic children. The treatment consists of an injection with a tiny diabetic sized syringe once a week. The duration depends on the severity of the disease. Research also reveals that in cancer cases that are stage I and II, the success rate approaches 90% inside 6 months. Nagalase and immune system levels can be measured in the blood and thus offer a marker for cancer and other diseases.

In conclusion, GcMAF restores the energetic balance in the cell. Cancer cells driven by sugar metabolism become healthy oxygen driven cells, so tumor cells no longer behave as parasitic organisms. GcMAF stimulates macrophages to consume the cancer cells and cells invaded by viruses. This stimulation of the immune system and the anti-angiogenetic effect surrounding the tumor is beneficial in cancer and several neurological disorders like autism, chronic fatigue, Parkinson’s, and Alzheimer’s, and it is available to the general public.

The following testimonials are from the  web site:


Hello Dr. Bradstreet, After 13 weeks of the GCMAF, we are happy to report that she continues to have tremendous gains in all areas. Increased socialization and speech, better performance in the school as well as community settings, decreased tantrums and less vocal protests, she is able to change activities and transition to non-preferred tasks. It has been absolutely amazing, all her therapists, teachers, other parents have remarked about her good behavior in public places (for example, grocery stores, department stores such as Nordstrom’s, Macy’s, The Zoo, Bowling, the library, parks and playgrounds. In the past, we never went to these places in fear of her stimming, or her behavior (45 minute tantrums). Now, she surprises us, as well as others, with her appropriate comments and follows direction very well. Before she would only eat one thing (french fries) and now she eats everything including vegetables!!!!! I’ve sent some pictures to show her progress. We are so excited to see what more phenomenal things are in the future to come!

Ovarian and lung cancer

I first contracted cancer in the form of a granulosa cell tumor in 2005. After 2 operations and 3 months of chemo by January 2010 it had reached stage 4 and had spread from my ovaries to my lungs. After that scan in January, I was told the chemo had failed. My 5 tumors were still growing [after] given Tamoxifen hormone [and] told I had between three months and two years left to live, and sent [me] on my way.

I started taking GcMAF at the age of 56 on May 16th, 2010. The only feeling or side effect I have from GcMAF is I felt almost from the beginning that I had my old energy back and was feeling much better and fitter in myself. After 8 weeks of taking only GcMAF and Tamoxifen I went for a scan. This showed all tumors had shrunk, the four in my lungs were now hardly noticeable and that the aggressive tumor in my pelvis had shrunk from 7.4cm to 4.1 cm. This is a significant decrease in size.

The stand-in consultant was very excited, and said these were excellent results. As I did not know her and she did not ask, I did not tell her why.

On the 21st Oct I had another scan; the improvements continued; the secondaries appeared to be merely scar tissue, and the pelvic tumor had shrunk to 3.5 cm.

In the winter my improvements seemed much slower; we now know because GcMAF needs normal vitamin D levels. But I’ve just got back from a wild month in Australia and Thailand. The sunshine should have done wonders for my vitamin D levels, and for my next scan. I will keep you updated. But I am over the moon and feel better than ever. And yes, you can phone me if you like. Gail in London.

Breast cancer

“I have the opportunity to treat patients from all over the World and the addition of GcMAF for my cancer patients is truly adding a new dimension not previously available to us. Recently I have been following a 42 year old women who had already undergone surgery, radiation and chemotherapy for stage IIIB breast cancer. I obtained a nagalase test through ELN (Holland) and it [showed] in the very elevated range of 4.20nmol/min/mg (normal reporting by this lab does not exceed 0.95). Her other tumor markers were not elevated, but her PET scan demonstrated a likely metastatic site in the hip bone.

After discussing her options the patient wanted to try GcMAF therapy prior to considering more radiation or chemotherapy. After 6 weeks of GcMAF 100ng/week subcutaneous injections (much like a shot of insulin) her repeat nagalase test returned at 2.10 (a 50% reduction). All of her other tumor markers remain negative and she is taking the dose of Vitamin D3 required to optimize her blood levels (9000 iu/day). It is too soon for her PET to be repeated but we will follow this soon to determine the course of the bone metastasis. The nagalase test may be a more sensitive marker for tumor burden than other more accepted blood tests. GcMAF given via simple patient administered once weekly injections is clearly able to reduce the nagalase level dramatically over a short period of time. In previous published studies, nagalase response to GcMAF was correlated with reduction and eventual elimination of cancer. This is an encouragement to us all and I will keep you posted on the patient’s progress.”

For more information please visit or contact David Noakes at:

First Immune GcMAF
Clos de Balade 21
1140 Evere
Brussels, Belgium
Phone +44-7781-411-737



(You may want to read the whole book. –MrT.)

Chapter 9: Nagalase: Friend and Foe?

By Timothy J. Smith, M.D.

What is Nagalase?

Nagalase is a protein made by all cancer cells and viruses (HIV, hepatitis B, hepatitis C, influenza, herpes, Epstein-Barr virus, and others). Its formal, official chemical name is alpha-N-acetylgalactosaminidase, but this is such a tongue-twisting mouthful of a moniker that we usually just call it “Nagalase.†(Sometimes, when I want to impress friends with my brilliance, I’ll say the entire word real fast: “alpha-N-acetylgalactosaminidase.†I have found that it’s important to practice beforehand if one doesn’t want to embarrass oneself.)

Why is Nagalase important?

Nagalase causes immunodeficiency. Nagalase blocks production of GcMAF, thus preventing the immune system from doing its job. Without an active immune system, cancer and viral infections can grow unchecked.

As an extremely sensitive marker for all cancers, Nagalase provides a powerful system for early detection.

Serial Nagalase testing provides a reliable and accurate method for tracking the results of any therapeutic regimen for cancer, AIDS, or other chronic viral infection.

Nagalase proves that cancer cells break all the rules

Normal healthy cells cooperate with one another in a concerted effort to further the good of all. Cancer cells refuse to play ball. Their disdainful attitude toward the rest of our cellular community is appalling. For example, these cellular scofflaws ignore clear messages to stop growing and spreading and encroaching on their neighbor’s space. How would you like it if your neighbor moved his fence over into your backyard?

Of all the rules cancer cells break, none is more alarming than the production of Nagalase, the evil enzyme that completely hog-ties the immune system army’s ability to stop cancer cells.

Virus particles also make Nagalase. Their goal is the same as that of the cancer cells: survival by incapacitating their number one enemy: the immune system.

Nagalase precision

Like a stealth bomber, the Nagalase enzyme synthesized in and released from a cancer cell or a virus particle pinpoints the GcMAF production facilities on the surface of your T and B lymphocytes and then wipes them out with an incredibly precise bomb. How precise? Let me put it this way: Nagalase locates and attacks one specific two-electron bond located at, and only at, the 420th amino acid position on a huge protein molecule (DBP), one of tens of thousands of proteins, each containing millions of electrons. This is like selectively taking out a park bench in a major city from six thousand miles away. More astonishing, if that is possible, Nagalase never misses its target. There is no collateral damage.

As you already know, GcMAF is a cell-signaling glycoprotein that talks to macrophages, enabling them to rapidly find, attack, and kill viruses and cancer cells. By activating macrophages, GcMAF triggers a cascade that activates the entire immune system. Blockage of GcMAF production by Nagalase brings all this wonderful anti-cancer and anti-viral immune activity to a screeching halt, allowing cancer and infections to spread.

What does Nagalase actually do? How does it destroy immune functioning and deactivate macrophages?

Once synthesized and released into nearby tissue or into the bloodstream, Nagalase, like that drill sergeant at boot camp, shouts harsh commands at the vitamin D binding protein (DBP) that is about to be turned into GcMAF. Nagalase demands that DBP not, under any circumstances, attach itself to a specific sugar molecule (galactosamine). If DBP has already grabbed (i.e., connected to, using a two-electron, “covalent†bond) a galactosamine sugar molecule, it is commanded to immediately let go. “Leave galactosamine alone, or you’ll be in big trouble!!!†is the Nagalase sergeant’s command. We’ll probably never know whether or not, on some deeper level, DBP knows that Nagalase’s motives are dastardly, but it doesn’t really matter: DBP will definitely always obey. Like the army private, the DBP literally has no choice. Because of the way hierarchies work in cellular biology, proteins must do the bidding of their enzymes. The enzymes, like Nagalase, are the drill sergeant and the proteins, like DBP, are the privates. That’s just the way it is. Obeying the drill sergeant’s command means DBP can’t do its assigned task, that of becoming GcMAF. It is rendered useless. For DBP, on a molecular level, life no longer has meaning.

Unfortunately for cancer and viral patients, DBP had been on its way to becoming GcMAF until the Nagalase drill sergeant so rudely interrupted. Now GcMAF, the one protein our bodies need in order to activate our immune systems, can’t be made. Immune activity screeches to a halt. The defense system protecting us from cancers and viruses has been snuffed out.

Nagalase, using this astonishingly simple yet cunningly subversive technique, emasculates the GcMAF precursor protein (DBP) by knocking off its three sugar molecules. One quick whack by Nagalase and the DBP protein that would have become a GcMAF molecule now limps off into the sunset, permanently disfigured and disabled. With one simple, swift maneuver, Nagalase has brought the entire immune system to its knees.

Here’s how Dr. Yamamoto put it (for clarity, I’ve replaced some of the technical words):

“Serum vitamin D3-binding protein (DBP) is the precursor for the principal macrophage activating factor (GcMAF). The precursor activity of serum DBP was reduced… These patient sera contained alpha-N-acetylgalactosaminidase (Nagalase) that deglycosylates (removes the sugars from) DBP. Deglycosylated DBP cannot be converted to GcMAF, thus it loses the GcMAF precursor activity, leading to immunosuppression.†(Microbes Infect. 2005 Apr;7(4):674-81. Epub 2005 Mar 22. Pathogenic significance of alpha-N-acetylgalactosaminidase activity found in the hemagglutinin of influenza virus. Yamamoto N, Urade M.)

Nagalase testing: former mass murderer now works for the good guys

It’s easy to be a little schizy about Nagalase. On the one hand, this nasty protein’s behavior toward us has been reprehensible and disastrous. Working in cahoots with cancer and HIV, not shy about getting into bed with our mortal enemies, Nagalase can rightfully claim direct responsibility for billions of human deaths. And it would just as soon add you to the list, so we don’t have to be shy about placing Nagalase in the “genocidal murderer†column.

With the advent of Nagalase testing, however, this bad actor now will be harnessed to a useful purpose. By providing us with precise and reliable advance information about enemy operations, Nagalase blood level testing becomes a “Deep Throat†double agent for cancer. He helps us by giving us an early warning sign.

Early detection (using AMAS or Nagalase) saves lives

You don’t want a cancer to have gotten out of control by the time you find and start treating it. When cancers are still young and small, gentle natural therapies are the most effective. Alternative treatments work best on early small cancers by enhancing immune functioning and removing the source of the inflammation that is causing the cancer in the first place. Cancers that have become large enough to see on imaging pose a much more significant threat, and the big guns now become necessary.

The current method for diagnosing most cancers requires us to wait until a mass shows up on imaging (e.g., a mammogram, chest X-ray, or colonoscopy). This approach wastes valuable time and causes needless deaths. But long before imaging can find it, a positive Nagalase (or ) can tell us that early stage cancer exists somewhere in the body. By enabling earlier and therefore less invasive treatment options, this information provides a huge head-start.

Normally present at only trace levels, Nagalase shows up in the blood when a cancer or virus appears

The malignant and viral entities that make Nagalase are not normally present, so its appearance is a big deal from a diagnostic perspective. When Nagalase shows up, even in very small amounts, we have the earliest glimpse of a new cancer or viral infection. The old adage, “Where there’s smoke, there’s fire†applies here. A positive Nagalase test notifies us that a cancer (or a nasty virus) lurks within.

Nagalase appears in the blood stream when a nascent cancer is just a minute cluster of abnormal cells, long before conventional diagnostic methods can detect it. Through blood testing, we can find this red flag, even when present at exceedingly low levels. Providing us with this early warning sign might not quite qualify Nagalase for the “Good Samaritan†award, but I could go with “extremely useful.†Like a rehabilitated criminal on parole, the potential for harm is still there. For now, however, he’s staying out of trouble and doing community service. Turn your back and he’s a mass murderer again.

Using Nagalase testing to track cancer treatment

Rising Nagalase levels indicate a cancer or virus is growing and spreading. Conversely, Nagalase levels will decrease if the cancer or infection is being effectively destroyed.

Any treatment that lowers cancer cell (or viral numbers) will lower Nagalase levels. Nagalase will, for example, always drop after surgery (whether or not the entire tumor was removed). Chemotherapy and radiation also reduce Nagalase levels. So does GcMAF. If, after these treatments, the depressed level begins to rise again, this is the warning sign that the cancer was not completely removed, and/or that metastatic disease is hiding out somewhere. With viral infections, increasing Nagalase levels indicate return of the infection.

Consecutive rising Nagalase levels are therefore a red flag, warning us it may be time to entertain new treatment options. Conversely, if levels are going down, stay the course: the cancer or virus is going away.

Flat-earth medicine

Many medical professionals don’t feel comfortable with “nonspecific†tests like Nagalase. It drives them nuts to discover that a cancer is lurking somewhere inside without knowing exactly where it is located. “How,†they ask, “do you expect me to treat a cancer I can’t see? Why, I’m not going to tilt at windmills!†This may be a signal that you need to find a different doctor, perhaps one who works in an alternative cancer clinic. Here you will find highly-trained professionals who understand the concept that cancer is a molecular biological change long before it presents visually (by this I mean becomes viewable on imaging).

When GcMAF becomes available, the answer will be easier: a six month course of weekly 100 ng GcMAF intramuscular injections with monthly Nagalase level tests to follow the Nagalase level as it goes back down to baseline. The cancer can be declared cured, even though it never reached life-threatening proportions. (We have a long way to go before this kind of medical behavior will be commonplace and acceptable. The sooner the better, however.)

Nagalase role “under-appreciatedâ€

Nagalase, arguably our most immunosuppressive protein molecule, poses an enormous threat in terms of cancer perpetuation and viruses’ ability to continually defeat us. Yet cancer researchers have not shown any interest in it. (Maybe I’m being a little too generous here; perhaps “clueless†would be more a more accurate depiction.) Why don’t they get it that blasting cancer cells into oblivion with chemo and radiation is usually not sufficient to stop advanced disease and does nothing to address the cause: immunosuppression. Even if we ignore for the moment the excessive collateral damage caused by chemo drugs and radiation, the patient also needs, or requires, a healthy immune system to finish the job. If we don’t revive immune function by disabling Nagalase, the cancers and viruses will just keep roaring back. Restoring immunocompetence by negating the stultifying effect of Nagalase should therefore become a primary research goal.


About the Author

Timothy J. Smith, M.D. has been studying and practicing alternative, nutritional, and conventional healing principles for over 40 years. A 1970 graduate of the University of Cincinnati College of Medicine, he completed his internship at the Pacific Medical Center in San Francisco and his residency at the University of California, San Francisco Medical Center. He subsequently established a general family practice in Berkeley, California, where he integrated conventional medical practice with alternative modalities. Dr. Smith’s current practice consists primarily of telephone consultations with patients around the world. He specializes in applying the principles of molecular biology to difficult diagnoses and designing alternative and anti-aging treatment programs.

Full bio:   (Worth reading. –MrT.)



GcMAF: The Latest Discovery in Natural Cancer Treatments

By Ulla Tervo
Dec. 2014

gcf, natural remedy for cancer, autism, image

An Italian molecular biologist, Marco Ruggiero, has invented a new ‘drug’, which is showing very promising results (according to WDDTY magazine, 1) in reversing not only cancer, but autism, autoimmune diseases, , multiple sclerosis, kidney disease, and other chronic illnesses as well, (WDDTY) magazine reports. The ‘drug’, however, is entirely natural and is composed of a special protein molecule combined with an unsaturated fatty acid (oleic acid) and vitamin D. The resulting complex molecule, GcMAF, needs enzymes produced by probiotic bacteria to be activated. The full treatment protocol, entitled the ‘Swiss Protocol’, includes a non-inflammatory diet (paleo-ketogenic diet), a special blend of probiotics, other supplements and amino acids. The protocol is offered to patients so far by Immuno Biotech in Switzerland and Germany. (Source: )

The beauty of this treatment is that it’s based on strengthening the body’s immune system. A special blend of probiotics, equal or similar to the blend in human colostrum (mother’s first milk), create enzymes, which then activate the GcMAF super-protein molecule, ‘What Doctors Don’t Tell You’ magazine writes. Gc proteins, which are naturally present in the human body, are used by the body and combined with unsaturated fatty acids (e.g. oleic acid) and vitamin D3 to create GcMAF proteins. Again, this is a natural process that happens in the human body, provided that the process is not hindered by lack of proper bacteria balance in the gut, the presence of substances that damage Gc proteins, or the lack of vitamin D3 and/or unsaturated fatty acids. The GcMAF protein then boosts the immune system, and enables macrophages (white blood cells) to do their job properly, i.e. to clean up cancer cells, attack tumors by making their surrounding cells excrete nitric oxide gas, eliminate viruses, etc. (Source: )

What is most intriguing about this discovery, in my opinion, is that it provides further evidence and information on why many claimed natural cancer remedies may work. If cancer, viruses and many other chronic illnesses can be overcome naturally by the body when the immune system is working at optimal capacity, then research into topics, such as vitamin C mega-dosing, Bob Beck protocol (including ), ozone therapies and other methods which also claim to work by maximizing the efficiency of the immune system (while being cheaper than GcMAF) becomes increasingly important and fascinating.

The Medlab magazine reports that GcMAF is likely to be the most potent immunotherapeutic tool in the fight against cancer, as well as autism, chronic fatigue syndrome and other neurological conditions. They say that GcMAF rebuilds a depressed immune system, and attribute this discovery to Dr. Yamamoto. (2)

Ruggiero discovered that the GcMAF molecule could not operate without binding to oleic acid. This was the missing link that more than 1000 researchers had been looking for, he states. ()

What Doctors Don’t Tell You magazine explains that Ruggiero, echoing many well-known researchers in the field, was frustrated by the focus of AIDS research, which was on the virus, rather than on its environment. Many were convinced that a person only became susceptible to the virus if the immune system was weakened, and that toxic living made a person susceptible to the virus. ()

“The microbe is nothing, the terrain is everything.” – Louis Pasteur

The body’s natural protein, GcMAF, increases energy production at the mitochondrial level, rebuilds a depressed immune system, activates white blood cells, increases neuronal (brain cell) connectivity and has also recently been shown to eradicate depression. (2)

Medlab magazine highlights that the GcMAF treatment must be coupled with changes in diet and lifestyle. “Daily vitamin D3, removing sugar and carbohydrates from the diet, decreasing stress, exercise, eating meat and fish are all essential components to beating cancer.” (2)

Cancer and virus particles make nagalase, an ‘evil enzyme’ that blocks the production of GcMAF and thus causes immunodeficiency, the online ‘GcMAF Book’, written by Dr. Timothy J. Smith, (3)

gcf, natural treatment for cancer, autism, kidney disease, image

Professor Ruggiero developed some new diagnosis tools as well, which help immensely with the detection and treatment of both cancer and autism. Ultrasonography can be used to accurately locate and measure tumors so that GcMAF can be placed directly on the tumor, the Medlab magazine says. Transcranial ultrasonography can be used to detect, measure, and classify autism in children as young as three months old. For the first time in autism history, autism spectrum disorder can be diagnosed in babies. This will allow specialists to intervene from an early age to avoid, or revert, the onset of autism. (2)

In addition, nagalase blood tests can be used to determine whether someone is at an increased risk of cancer. (3)

GcMAF with oleic acid (GOleic) can be injected near a tumor, given as a suppository to bypass the stomach for liver cancer or delivered via a nebulizer spray for lung cancer. Even transcranial ultrasound has been used for brain cancer to puncture a ‘hole’ in the blood-brain barrier so as to allow the delivery of GcMAF ‘supermolecule’ directly into the tumor. The product can also be taken as drops under the tongue, in enemas, applied as ointment and used as mouthwash, What Doctor’s Don’t Tell You magazine explains. (1)

On the website, a for a cancer with tumors is provided, as follows (direct quote):

“For stage one, a standard dose of 0.25ml GOleic twice a week, for stage 2 three doses a week, late stage 4 up to a full 1ml a day. The more the better. 2ml a day has been taken without side effects.”

“10,000 IU of vitamin D a day”

“Eat white meat, fish and vegetables”

“No sugar or carbohydrates (so no cereals or bread, etc.) which feed cancer”

“If your weight drops below your perfect weight for your height, take Branch Chain Amino Acids (BCAA) from a vitamin shop, or better, Master Amino Acid Pattern (MAP) from Dr. Reinwald Healthcare.”

Read the more detailed instructions by going to the referenced website.

also recommends for people to avoid the four main causes of cancer: too much sugar, lack of vitamin D3, poor nutrition lacking in amino acids and trace metals, lack of oxygen and exercise and severe shock stress.

reports and provides evidence that their method can eradicate or treat chronic , , , chronic , , myalgic encephalomyelitis (ME, ), Crohn’s disase, , cirrhosis of the liver, chronic kidney disease, wound healing, chronic , hepatitis, , periodontal disease, psoriasis, allergies, , , , , , , and metastases.

The Conscious Evolution Media (CEM) website provides to a TV series Dr. Marco Ruggiero did on the .

For further information refer to , and as well as to the source article, below. The GcMAF website provides links to scientific research papers. Saisei Mirai Clinics in Japan also offer GcMAF treatments – – and possibly other collaborating clinics do as well elsewhere in the world. There is also a “GcMAF” Facebook group.

The images are published with consent from GcMAF.eu.
Published with consent from ‘What Doctors Don’t Tell You’ magazine.


(1) (WDDTY): November 2014: “GcMAF, Superhero?”
(2) Medlab Magazine:
(3) by Dr. Timothy J. Smith


(You have to subscribe to read entire article. –MrT.)


Ulla Tervo is the Editor of Cheap Health Revolution, covering natural remedies and health solutions.


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